Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells

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Abstract

Autoantibody against nicotinic acetylcholine receptor (nAChR) α3 subunit has been implicated in the pathogenesis of paraneoplastic neurological syndrome. To examine the effect of anti-α3 subunit autoantibody on cell-surface nAChRs, we established human embryonic kidney 293 cells stably co-expressing α3 and β4 subunits. Upon incubation with seropositive patient's serum, this cell line showed co-accumulation of patient's IgG and α3 subunits in the cytoplasm. These data support the hypothesis that anti-α3 subunit autoantibody induces internalization of cell-surface nAChRs and thereby impairs synaptic transmission. © 2012 Elsevier B.V. All rights reserved.

Journal

  • Journal of Neuroimmunology

    Journal of Neuroimmunology 257(1-2), 102-106, 2013-04-15

    Elsevier B.V.

Codes

  • NII Article ID (NAID)
    120005253252
  • NII NACSIS-CAT ID (NCID)
    AA1045958X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0165-5728
  • Data Source
    IR 
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