Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

• Kitagawa, Noriko

• Kondo, Satoru

• Wakisaka, Naohiro

• Zen, Yoh

• Nakanishi, Yosuke

• Tsuji, Akira

• Endo, Kazuhira

• Murono, Shigeyuki

• Yoshizaki, Tomokazu

Abstract

Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis. © 2012 Elsevier Ireland Ltd.

Journal

• Cancer Letters

  Cancer Letters 331 (1), 52-57, 2013-04-30

  Elsevier

Keywords

• Epstein-Barr virus (EBV)
• Hypoxia-inducible factor 1 alpha (HIF1α)
• Latent membrane protein 1 (LMP1)
• Nasopharyngeal carcinoma
• Seven-in-absentia homologue 1 (Siah1)

Details

• CRID: 1050282810960602880
• NII Article ID: 120005253837
• NII Book ID: AA00598513
• ISSN: 03043835
• Web Site: http://hdl.handle.net/2297/34135
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles