EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.

• Ueda, Tomoko

• Hanai, Ayako

• Takei, Tomomi

• Kubo, Keiji

• Ohgi, Minako

• Sakagami, Hiroyuki

• Takahashi, Senye

• Shin, Hye-Won

• 中山, 和久

抄録

The small GTPase Arf6 is transiently associated with the ingressing cleavage furrow and subsequently targeted to the Flemming body during cytokinesis, suggesting its activation around the cleavage furrow. Here, we show that EFA6 (exchange factor for Arf6) localizes on the cleavage furrow through its PH domain. Time-lapse analysis showed that both EFA6 and Arf6 are transiently localized around the ingressing cleavage furrow, but only Arf6 is subsequently targeted to the Flemming body. Expression of an EFA6 mutant suppresses Arf6 recruitment onto the Flemming body. These results suggest that EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis.

収録刊行物

• FEBS letters

  FEBS letters 587 (11), 1617-1623, 2013-06-05

  Elsevier BV

キーワード

• Arf6
• Cleavage furrow
• Cytokinesis
• EFA6
• Flemming body
• PH domain

詳細情報

• CRID: 1050282810746624256
• NII論文ID: 120005293580
• NII書誌ID: AA00642943
• ISSN: 00145793
• ISSN: 18733468
• HANDLE: 2433/175267
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN