Effects of parabens on apoptosis induced by serum-free medium.

• Egawa, Mari

• Aoki, Kentaro

• Sun, Yongkun

• Hosokawa, Toshiyuki

• Saito, Takeshi

• Kurasaki, Masaaki

Abstract

Alkyl esters of p-hydroxybenzoic acids (parabens), an endocrine disrupter, are used as preservatives in cosmetics and foods. In this study, to understand the relationship between parabens and differentiation in infants, the effects of parabens on apoptosis induced by serum deprivation in PC12 cells were investigated. In addition, apoptosis-related factors were assayed. As results, a tendency toward enhancement of apoptosis was observed in the cells cultured in the serum-free medium with methylparaben, and this tendency was suggested to be related to the contents of BAD, a pro-apoptotic protein. Butylparaben did not show any tendency to enhance apoptosis.

Journal

• Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 47 (3), 196-204, 2012-03

  Taylor & Francis

Keywords

• PC12 cell
• endocrine disrupter
• food additives
• apoptotic factors
• methylparaben
• butylparaben

Details

• CRID: 1050282813987296768
• NII Article ID: 120005303468
• NII Book ID: AA00697424
• ISSN: 15324109
• ISSN: 03601234
• HANDLE: 2115/52989
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles