PARAQUAT ENHANCES NEPHROCALCINOSIS UNDER MG RESTRICTION IN THE DIET

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  • マグネシウム制限食餌下でのパラコート投与による腎臓石灰化の促進

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Abstract

This study has been undertaken to determine which organs are damaged by herbicide paraquat (PQ) under restriction of Mg and other minerals. Experiments were made with osteogenic disorder Shionogi rats, which lack the ability of synthesizing vitamin C like humans. The dietary Mg or mineral-mixture was given to the rats according to either the concentration or half of it recommended by American Institute of Nutrition. The dose of PQ was either 483 or 965 nmol/g diet. The concentrations of PQ, vitamin C radical and kininogen in tissues or plasma were measured to assess the severity of injury. Tissue levels of several metals, such as Mg, Ca, Fe, Cu and Zn, were also quantitated, because severe PQ toxicity appeared under Mg restriction or the mineral-mixture restriction showing the close relation between PQ toxicity and metals. The most notable change in metal levels caused by the synergistic effect of restriction of either Mg or the mineral-mixture plus dosing of PQ appeared for kidney Ca; the concentration of kidney Ca increased 10 times the control value under Mg restriction and 28 times the control value under the mineral-mixture restriction. The kidney PQ level of the Mg restricted or the mineral-mixture restricted rats was higher than that of the rats dosed with larger amounts of PQ under sufficient mineral supply. These results indicate that the kidney is the target organ of PQ under Mg restriction or mineral-mixture restriction, and suitable amounts of minerals in the diet are useful to reduce chronic PQ toxicity.

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