ANALYSIS OF BUTYROPHENONES IN WHOLE BLOOD SPECIMENS BY LC/MS/MS USING A NEW POLYMER COLUMN

• Hattori, Hideki

• Arinobu, Tetsuya

• Iwai, Masae

• Masuda, Kenji

• Suzuki, Osamu

• Seno, Hiroshi

Bibliographic Information

Other Title

• ポリマーカラムを用いた全血中ブチロフェノン系薬物のLC/MS/MS分析

Abstract

Seven butyrophenones in human whole blood were analyzed by LC/MS/MS using a new polymer column (MSpak GF-310), which enabled direct injection of crude biological samples without complicated pretreatments. The quantitation was made by mass chromatography for each product ion, The recoveries were more than 50% for haloperidol, bromperidol, moperone and spiroperidol at 80 ng/ml in whole blood, but less than 10% for pimozide. The regression equations showed good linearity for haloperidol, bromperidol, moperone and spiroperidol in the range of 10-80 ng/ml, for timiperone in the range of 20-80 ng/ml and for pimozide in the range of 50-200 ng/ml using the chlorinated analog of haloperidol as internal standard, Their detection limits were about 5 ng/ml for haloperidol, bromperidol, moperone and spiroperidol, about 10 ng/ml for timiperone and about 25 ng/ml for pimozide. Thus, the present method seems useful for sensitive and specific detection and determination of their high therapeutic and toxic levels present in biological specimens including whole blood.

Journal

• Japanese journal of forensic toxicology

  Japanese journal of forensic toxicology 23 (1), 13-17, 2005-01-31

  日本法中毒学会

Keywords

• Butyrophenones
• Haloperidol
• Bromperidol
• Moperone
• Spiroperidol
• LC/MS/MS
• New polymer column (MSpak GF-310)
• Whole blood

Details

• CRID: 1050001201666689536
• NII Article ID: 120005314065
• ISSN: 09159606
• HANDLE: 10271/1749
• Web Site: https://hama-med.repo.nii.ac.jp/records/1716
• Web Site: https://search.jamas.or.jp/link/ui/2006137582
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles