The serum vaspin levels are reduced in Japanese chronic hemodialysis patients

• Inoue, Junko

• Wada, Jun

• Teshigawara, Sanae

• Hida, Kazuyuki

• Nakatsuka, Atsuko

• Takatori, Yuji

• Kojo, Shoichirou

• Akagi, Shigeru

• Nakao, Kazushi

• Miyatake, Nobuyuki

• McDonald, John F.

• Makino, Hirofumi

抄録

Background: Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients. Methods: Healthy Japanese control volunteers (control; n = 95, 49.9 +/- 6.91 years) and Japanese patients undergoing hemodialysis therapy (HD; n = 138, 51.4 +/- 10.5 years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system. Results: The measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n = 5) and HD patients (n = 11) exhibited much higher levels (> 10 ng/ml; Vaspin(High) group), while the rest of the population exhibited lower levels (< 3 ng/ml; Vaspin(Low) group). By comparing the patients in the Vaspin(Low) group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87 +/- 0.24 ng/ml) than in the HD patients (0.32 +/- 0.15 ng/ml) (p < 0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects. Conclusions: The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the Vaspin(Low) group.

収録刊行物

• BMC Nephrology

  BMC Nephrology 13 2012-12-03

  Biomed Central Ltd

キーワード

• Adipokine
• End-stage renal disease
• Hemodialysis

詳細情報

• CRID: 1050565162652512640
• NII論文ID: 120005315579
• ISSN: 14712369
• Web Site: https://ousar.lib.okayama-u.ac.jp/50624
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles