Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids.

• Nakagawa, Takayuki

• Ogino-Nishimura, Eriko

• Hiraumi, Harukazu

• Sakamoto, Tastunori

• Yamamoto, Norio

• Ito, Juichi

Abstract

[Objective]: To examine the effects of topically applied recombinant human insulin-like growth factor 1 (IGF1) via gelatin hydrogels on alterations in pure-tone audiometry (PTA) in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic steroids. [Study Design]: Retrospective chart review. [Setting]: A single university hospital. [Patients]: Twenty-five patients with SSHL refractory to systemic steroids who received topical IGF1 treatment. [Intervention]: Single topical application of IGF1 to the round window niche using gelatin hydrogels. [Main Outcome Measures]: The primary outcome was alterations in PTA thresholds at frequencies of 0.25, 0.5, 1, 2, and 4 kHz after topical IGF1 application. Secondary outcomes included differences in final improvements in PTA thresholds among frequencies tested and cumulative numbers of patients showing 10- or 20-dB recovery in PTA during the observation period. [Results]: Topical IGF1 application via gelatin hydrogels significantly altered PTA thresholds at each frequency tested and at the average frequency. The numbers of patients with a 10-dB recovery in PTA increased until 4 weeks after treatment and then stabilized, whereas those patients showing 20-dB recovery gradually increased during the observation period. [Conclusion]: Topical IGF1 application via gelatin hydrogels contributes to the recovery of PTA levels in patients with SSHL refractory to systemic steroids. Major recovery of PTA levels occurs within 4 weeks after treatment.

Journal

• Otology & neurotology

  Otology & neurotology 33 (6), 941-946, 2012-08

  Lippincott, Williams & Wilkins

Keywords

• Drug delivery system
• Growth factor
• Local application
• Sudden sensorineural hearing loss
• Administration, Topical
• Adult
• Aged
• Audiometry, Pure-Tone
• Auditory Threshold/drug effects
• Drug Resistance
• Female
• Hearing Loss, Sensorineural/drug therapy
• Hearing Loss, Sudden/drug therapy
• Humans
• Hydrogels
• Insulin-Like Growth Factor I/administration & dosage
• Insulin-Like Growth Factor I/therapeutic use
• Male
• Middle Aged
• Recombinant Proteins/administration & dosage
• Recombinant Proteins/therapeutic use
• Retrospective Studies
• Round Window, Ear
• Steroids/therapeutic use
• Treatment Outcome
• Young Adult

Details

• CRID: 1050845760707940480
• NII Article ID: 120005323028
• ISSN: 15374505
• HANDLE: 2433/178678
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles