NicotineによるMethamphetamineのマウス移所運動促進効果に対する増感現象の修飾－Methamphetamine乱用量の増加と精神毒性増強の可能性－

IR

Bibliographic Information

Other Title
  • Modification by Nicotine of the Sensitization to Methamphetamine-induced Ambulatory Stimulation in Mice: Possibility of Increase in Methamphetamine Dose of Abuse and Enhancement of Its Psychotoxicity

Abstract

Since methamphetamine (MAP) has been frequently inhaled simultaneously with nicotine, i.e., cigarette smoking mixed with MAP, the modification by nicotine of the behavioral sensitization to MAP was evaluated in terms of ambulatory activity in mice. During the 5 repeated co-administrations of MAP (2 mg/kg s.c.) with nicotine (0.03, 0.1, 0.3 and 1 mg/kg s.c.) at 3 day intervals, nicotine dose-dependently inhibited the progressive enhancement of MAP-induced ambulatory stimulation. However, such pre-treatments did not modify the induction of ambulatory sensitization to MAP (2 mg/kg s.c.). In both the drug-naive and MAP-sensitized mice, nicotine reduced the ambulatory stimulant effect of MAP. These results suggest that, although nicotine reduces the expression of ambulatory stimulant effect of MAP, nicotine does not protect, but rather accelerate, the induction of psychotoxic effect of MAP.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top