Effect of Insulin on Mitochondrial Respiratory Control and Oxidative Phosphorylation of Alloxan Diabetic Rats : A Possible New Action of Insulin on Liver Mitochondria

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Respiratory control index and ADP/0 ratio of the liver mitochondria from a group of alloxan diabetic rats were significantly decreased compared to a normal group. Insulin treatment on alloxan diabetic rats improved both indexes up to the normal levels. However, insulin addition in vitro into mitochondria suspension had no effect on the both indexes. It was found that insulin addition in vitro blocks the uncoupled respiration induced by 2, 4-dinitrophenol. One of insulin actions, a disulfide hormone, in vivo was proposed to protect mitochondria from uncoupling factor in connection with thioldisulfide interchange to produce the conformational in mitochodria membrane. The reason of reduced efficiency of oxidative phosphorylation in alloxan diabetic rats might be partly due to lack of protective action of insulin.


  • Nagoya Journal of Medical Science

    Nagoya Journal of Medical Science 32(1), 45-53, 1969-07

    Nagoya University School of Medicine


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