Sensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collier

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Abstract

神経細胞の個性を生み出すしくみの解明 -サブタイプ特異的な形づくりの遺伝子プログラム-. 京都大学プレスリリース. 2013-11-28.

The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits.

Journal

  • Developmental Cell

    Developmental Cell (27), 2013-12-09

    Elsevier B.V.

Codes

  • NII Article ID (NAID)
    120005348995
  • NII NACSIS-CAT ID (NCID)
    AA11561311
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1534-5807
  • Data Source
    IR 
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