Sensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collier

• Hattori, Yukako

• Usui, Tadao

• Satoh, Daisuke

• Moriyama, Sanefumi

• Shimono, Kohei

• Itoh, Takehiko

• Shirahige, Katsuhiko

• Uemura, Tadashi

Abstract

The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits.

Journal

• Developmental Cell

  Developmental Cell 27 (5), 530-544, 2013-12-09

  Elsevier B.V.

Keywords

• Developmental Biology
• Cell Biology
• General Biochemistry, Genetics and Molecular Biology
• Molecular Biology

Details

• CRID: 1050001335777986688
• NII Article ID: 120005348995
• NII Book ID: AA11561311
• ISSN: 15345807
• DOI: 10.1016/j.devcel.2013.10.024
• HANDLE: 2433/179534
• Web Site: https://api.elsevier.com/content/article/PII:S1534580713006412?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1534580713006412?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN