Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome

• Fujieda, Yuichiro

• Atsumi, Tatsuya

• Amengual, Olga

• Odani, Toshio

• Otomo, Kotaro

• Kato, Masaru

• Oku, Kenji

• Kon, Yujiro

• Horita, Tetsuya

• Yasuda, Shinsuke

• Koike, Takao

Abstract

Objective: To study the clinical and immunological manifestations of the antiphospholipid syndrome (APS) in Japanese population by a single center registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling the Sydney revised Sapporo criteria for definite APS, who visited to our Autoimmune Clinic from 1988 to 2010 were recruited and followed up. All the patients were interviewed and underwent a general physical examination by qualified rheumatologists on the day of blood sampling. Results: The population comprised 119 woman and 22 men with a mean age at diagnosis of 44 years (range 11-83 years). Seventy patients (49.6%) had primary APS, and 71 (50.4%) had systemic lupus erythematosus. The prevalence of thrombosis was 85.8%, arterial thrombosis was found in 93 patients (66.0%) and venous thrombosis in 46 (32.6%). The most common thrombosis was cerebral infarction [86/141 (61.0%)] followed by deep vein thrombosis [33/141 (23.4%)]. Among 70 pregnant women, 45 (64.3%) had obstetric complications. Lupus anticoagulant was detected in 116 patients (82.3%), anticardiolipin antibodies in 83 (58.9%), anti-β2Glycoprotein I antibodies in 73 (51.8%) and phosphatidylserine-dependent antiprothrombin antibodies in 98 (69.5%). Conclusion: High prevalence of arterial thrombosis was noted in Japanese patients with APS. The profile of heterogeneous and complex clinical manifestations in was substantiated in Japanese patients with APS.

Journal

• Lupus

  Lupus 21 (14), 1506-1514, 2012-12

  SAGE Publications

Keywords

• Anticardiolipin antibody
• antiphospholipid antibodies
• antiprothrombin antibody
• arterial thrombosis
• lupus anticoagulant
• obstetric complications
• phosphatidylserine dependent
• venous thrombosis

Details

• CRID: 1050001202567094912
• NII Article ID: 120005356853
• HANDLE: 2115/54013
• ISSN: 09612033
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles