Long-term Observation of Osteomalacia Caused by Adefovir-Induced Fanconi’s Syndrome

• Terasaka Tomohiro

• Ueta Eijiro

• Ebara Hirotaka

• Waseda Koichi

• Hanayama Yoshihisa

• Takaki Akinobu

• Kawabata Tomoko

• Sugiyama Hitoshi

• Hidan Ko

• Otsuka Fumio

抄録

A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 68 (1), 53-56, 2014-02

  Okayama University Medical School

キーワード

• adefovir dipivoxil (ADV)
• eldecalcitol
• Fanconi's syndrome
• hypophosphatemia
• osteomalacia

詳細情報

• CRID: 1390290699796057856
• NII論文ID: 120005372647
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/52145
• PubMed: 24553490
• Web Site: https://ousar.lib.okayama-u.ac.jp/52145
• Web Site: https://search.jamas.or.jp/link/ui/2014376400
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles