ラット口蓋癌由来培養細胞の生物学的性状解明

• 伊東 博司

• 奥山 典子

• 阿部 匡聡

• 櫻井 裕子

• 遊佐 淳子

• 堀内 登

• 山崎 章

• イトウ ヒロシ

• オクヤマ ノリコ

• アベ マサトシ

• サクライ ユウコ

• ユサ ジュンコ

• ホリウチ ノボル

• ヤマサキ アキラ

• Hiroshi ITO

• Noriko OKUYAMA

• Masatoshi ABE

• Yuuko SAKURAI

• Junko YUSA

• Noboru HORIUCHI

• Akira YAMASAKI

書誌事項

タイトル別名

• Biological Characteristics of a New Cell Strain Isolated from a Squamous Cell Carcinoma of the Rat Palate

抄録

4-nitroquinoline N-oxide (4NQO) administrated rats have high occurrence of palatal squamous cell carcinoma (SCO, which almost always accompanies resorption of the jaw bone. We have developed a cell strain (11/8F) from a rat palatal SCC induced by 4NQO administration. The cultured cells are polygonal or round in shape, and they exhibited cobble-stone growth pattern. Immunocytochemically, 11/8F cells were positive with four anti-cytokeratin antibodies; AE1, AE3, CAM5.2, and KL1. It is also found that an immunoreactivity for parathyroid hormone-related protein (PTHrP), which is closely related to cancerous bone resorption. In addition, expression of PTHrP mRNA were identified. The cell strain 11/8F, exhibiting characters as noted above, might permit establshing an experimental model to clarify mechanisms of bone destruction with oral SCC invasion.

収録刊行物

• 奥羽大学歯学誌

  奥羽大学歯学誌 33 (1), 49-55, 2006-03-31

キーワード

• cell culture
• oral squamous cell carcinoma
• bone resorption
• rat

詳細情報

• CRID: 1570291227702096896
• NII論文ID: 120005409183
• NII書誌ID: AN1010214X
• Web Site: http://id.nii.ac.jp/1173/00002488/
• 本文言語コード: ja
• データソース種別:
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