向精神薬のターゲット部位の遺伝子解析 : セロトニントランスポーター遺伝子多型とパーソナリティおよび痛覚との関連研究  [in Japanese] Genetic analysis of targets for psychotropic drugs : association among genetic polymorphism of serotonin reuptake transporter personality, and pain threshold  [in Japanese]

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Abstract

我々はセロトニントランスポーター (5-HTT) 3'非翻訳領域 (3'UTR) 遺伝子多型の影響, 疼痛感受性個人差の原因, 性格の遺伝要因を解明する一助として5-HTT 3'UTR遺伝子多型と痛覚閾値およびパーソナリティとの3つの要因の関連性について調査検討を行った。 181人の健常者を対象に, 5-HTT 3'UTR遺伝子多型の判定には制限酵素切断長多型解析法を用い, 痛覚閾値に関しては冷水刺激試験および圧刺激試験を, パーソナリティの測定にはTCI (Temperament and Character Inventory) を行った。 遺伝子多型と痛覚閾値には関連がなかった。遺伝子多型とTCIの相関について, 男性ではST3{超個人的同一化 (vs. 自己弁別)}が遺伝子型G/G群で有意に高く, 女性ではST (自己超越性総合点) およびST2{自己忘却 (vs. 自己意識経験)}が遺伝子型G/T + T/T群で有意に高かった。痛覚閾値とTCIとの関係について, 男性群で冷水刺激閾値とNS4{無秩序 (vs. 組織化)}およびNS (新奇性追求) で負の相関, 女性群で冷水刺激閾値とSD4 (自己受容), C5{純粋な良心 (vs. 利己主義)}および圧刺激閾値とSD4 (自己受容) で正の相関が認められた。本研究から5-HTT 3'UTR遺伝子多型はCloningerの理論における性格次元に影響を与える可能性がある一方で, 痛覚は5-HTT 3'UTR遺伝子多型と関与せず, 一方でパーソナリティの一部と相関関係にある可能性が示唆された。

To estimate the genetic factors influencing individual differences in sensitivity to pain, we have examined the associations among serotonin reuptake transporter (5-HTT) 3' UTR gene polymorphism, sensitivity to pain and personality. After the procedures were fully explained and written informed consent was obtained, 5-HTT 3' UTR gene polymorphism was investigated by PCR-RFLP, and personality assessment was performed by means of Temperament and Character Inventory (TCI), and pain threshold by means of cold water and pressure stimulation tests in 181 healthy Japanese volunteers. Males with the T allele (T/T and T/G) showed a significantly lower Self-Transcendence (ST) 3 subdimension score than those without the T allele (G/G). Females with the T allele (T/T and T/G) showed significantly higher ST2 subdimension and ST dimension scores than those without the T allele (G/G). There was no significant relationship between 5-HTT 3' UTR gene polymorphism and pain sensitivity. As for pain sensitivity and TCI, there was low negative correlation between cold water stimulation in males and Novelty Seeking (NS) 4 subdimension and NS, and low positive correlation between cold water stimulation in females and Self-Directedness (SD) 4 subdimension and Cooperativeness (C) 5 subdimension, and between pressure stimulation in females and SD4. It is possible that 5-HTT 3' UTR gene polymorphism may affect the character dimension in the theory of Cloninger, however, 5-HTT 3' UTR gene polymorphism may not be related to the sense of pain, and that there is low correlation between pain and a part of the personality.

Journal

  • 麻布大学雑誌 = Journal of Azabu University

    麻布大学雑誌 = Journal of Azabu University (17/18), 115-119, 2009-03-31

    Azabu University

Codes

  • NII Article ID (NAID)
    120005419264
  • NII NACSIS-CAT ID (NCID)
    AA11561468
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • ISSN
    1346-5880
  • Data Source
    IR 
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