Biotin and carnitine deficiency due to hypoallergenic formula nutrition in infants with milk allergy

• Hayashi Hisako

• Tokuriki Shuko

• Okuno Takashi

• Shigematsu Yosuke

• Akiba Yasushi

• Matsuyama Go

• Sawada Ken

• Ohshima Yusei

Abstract

Amino acid formulas and hydrolyzed formulas given to infants in Japan with milk allergies theoretically contain little, if any, biotin and carnitine. We assessed biotin and carnitine insufficiency in six infants with milk allergy who were fed amino acid formulas and/or hydrolyzed formulas, by measuring urine 3-hydroxyisovaleric acid (3- HIA) and serum free carnitine ( C0), respectively. All patients presented with elevated urine 3- HIA and lowered serum C0 compared with post-menstrual age-matched infants who were fed breast milk or standard infant formulas. Supplementation with biotin and l-carnitine immediately improved the insufficiency. Care should be taken to avoid biotin and carnitine deficiency in allergic infants fed amino acid or hydrolyzed formulas.

Journal

• Pediatrics International

  Pediatrics International 56 (2), 286-288, 2014-04

  Wiley Blackwell

Keywords

• amino acid formula
• biotin deficiency
• camitine deficiency
• milk allergy

Details

• CRID: 1570291227707701248
• NII Article ID: 120005428403
• ISSN: 13288067
• Web Site: http://hdl.handle.net/10098/8249
• Web Site: https://search.jamas.or.jp/link/ui/2015190313
• Text Lang: en
• Data Source:
  • CiNii Articles