MicroRNA expression profiling of cat and dog kidneys

• Ichii, Osamu

• Otsuka, Saori

• Ohta, Hiroshi

• Yabuki, Akira

• Horino, Taro

• Kon, Yasuhiro

抄録

MicroRNAs (miRNAs) play a role in the pathogenesis of certain diseases and may serve as biomarkers. Here, we present the first analysis of miRNA expression in the kidneys of healthy cats and dogs. Kidneys were divided into renal cortex (CO) and medulla (MD), and RNA sequence analysis was performed using the mouse genome as a reference. A total of 277, 276, 295, and 297 miRNAs were detected in cat CO, cat MD, dog CO, and dog MD, respectively. By comparing the expression ratio of CO to MD, we identified highly expressed miRNAs in each tissue as follows: 41 miRNAs including miR-192-5p in cat CO; 45 miRNAs including miR-323-3p in dog CO; 78 miRNAs including miR-20a-5p in cat MD; and 11 miRNAs including miR-132-5p in dog MD. Further, the target miRNAs of these miRNAs were identified. These data provide veterinary medicine critical information regarding renal miRNA expression. (C) 2014 Elsevier Ltd. All rights reserved.

収録刊行物

• Research in Veterinary Science

  Research in Veterinary Science 96 (2), 299-303, 2014-04

  Elsevier

キーワード

• Companion animals
• Cat
• Dog
• MicroRNA
• Kidney
• RNA sequencing

詳細情報

• CRID: 1050001202675065472
• NII論文ID: 120005446629
• HANDLE: 2115/56453
• ISSN: 00345288
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles