Mathematical modeling of calcium waves induced by mechanical stimulation in keratinocytes

• Kobayashi, Yasuaki

• Sanno, Yumi

• Sakai, Akihiko

• Sawabu, Yusuke

• Tsutsumi, Moe

• Goto, Makiko

• Kitahata, Hiroyuki

• Nakata, Satoshi

• Kumamoto, Junichi

• Denda, Mitsuhiro

• Nagayama, Masaharu

抄録

Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on experimental observations of in vitro calcium waves in keratinocytes induced by mechanical stimulation, and present a mathematical model that can describe the experimentally observed wave behavior that includes finite-range wave propagation and a ring-shaped pattern. A mechanism of the ring formation hypothesized by our model may be related to similar calcium propagation patterns observed during the wound healing process in the epidermis. We discuss a possible extension of our model that may serve as a tool for investigating the mechanisms of various skin diseases.

収録刊行物

• PLoS One

  PLoS One 9 (3), e92650-1-e92650-10, 2014-03-24

  Public Library of Science (PLoS)

詳細情報

• CRID: 1050282813992505984
• NII論文ID: 120005457012
• ISSN: 19326203
• HANDLE: 2115/56610
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles