Association between anti-U1 ribonucleoprotein antibodies and inflammatory mediators in cerebrospinal fluid of patients with neuropsychiatric systemic lupus erythematosus.

• Yokoyama, T

• Fujii, T

• Kondo-Ishikawa, S

• Yamakawa, N

• Nakano, M

• Yukawa, N

• Yoshifuji, H

• Ohmura, K

• Mimori, T

Abstract

[Objective] We investigated possible associations between neurotoxic inflammatory mediators (IMs) and anti-U1RNP antibodies (Abs) in cerebrospinal fluid (CSF) of neuropsychiatric systemic lupus erythematosus (NPSLE). [Methods] Serum and CSF anti-U1RNP Abs were detected using an RNA-immunoprecipitation assay and CSF anti-U1RNP Ab levels were measured by ELISA. IFN-α, MCP-1 and IL-8 levels in CSF were determined by quantitative multiplex cytokine analysis. IM levels were compared among anti-U1RNP-positive and anti-U1RNP-negative NPSLE as well as other rheumatic disease controls (controls). [Results] Anti-U1RNP Abs were detected in serum (58%) and in CSF (18%) of 82 NPSLE patients. CSF MCP-1 levels were higher in NPSLE than in controls. CSF IFN-α level was higher in CSF anti-U1RNP Ab-positive than in -negative patients or controls. When limited to serum anti-U1RNP Ab-positive patients, however, levels of all three IMs in CSF were higher in CSF anti-U1RNP Ab-positive than in -negative patients. Anti-U1RNP Ab levels in CSF correlated with CSF MCP-1, but not IFN-α and IL-8 levels. Conclusions CSF anti-U1RNP Ab positivity is associated with increased level of CSF IFN-α. MCP-1 levels correlated with CSF anti-U1RNP Ab levels, whereas the increased CSF MCP-1 was not specific to CSF anti-U1RNP Ab-positive NPSLE.

Journal

• Lupus

  Lupus 23 (7), 635-642, 2014-05-30

  SAGE Publications

Keywords

• Anti-U1RNP antibodies
• cerebrospinal fluid
• IFN-α
• MCP-1
• neuropsychiatric systemic lupus erythematosus

Details

• CRID: 1050564285747738880
• NII Article ID: 120005458289
• ISSN: 09612033
• HANDLE: 2433/189096
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles