Human intestinal spirochetosis is significantly associated with sessile serrated adenomas/polyps

• Omori, Saori

• Mabe, Katsuhiro

• Hatanaka, Kanako

• Ono, Masayoshi

• Matsumoto, Mio

• Takahashi, Masakazu

• Yoshida, Takeshi

• Ono, Shoko

• Shimizu, Yuichi

• Sugai, Nozomi

• Suzuki, Akira

• Katsuki, Shinichi

• Fujii, Takahiro

• Kato, Mototsugu

• Asaka, Masahiro

• Sakamoto, Naoya

抄録

It remains unclear whether or not human intestinal spirochetosis (HIS) has any associated symptoms or lesions. In this study, we assessed the prevalence of HIS in sessile serrated adenomas/polyps (SSA/Ps) and their possible association. Following identification of early cecal cancer with SSA/P accompanied by a colonization of HIS, we went on to conduct a retrospective case-control study using endoscopically resected SSA/P specimens to examine the frequency of HIS infection in SSA/Ps. Nineteen SSA/P cases and 172 controls were obtained. The rate of HIS infection was significantly higher at 52.6% (10/19) in the SSA/P cases compared to the controls at 8.1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps. (C) 2014 Elsevier GmbH. All rights reserved.

収録刊行物

• Pathology, Research and Practice

  Pathology, Research and Practice 210 (7), 440-443, 2014-07

  Elsevier

キーワード

• Human intestinal spirochetosis
• Sessile serrated adenoma/polyps
• Serrated lesion

詳細情報

• CRID: 1050564288970261120
• NII論文ID: 120005462415
• NII書誌ID: AA00769966
• HANDLE: 2115/56700
• ISSN: 03440338
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles