Renal Distribution of Vasohibin-1 in Patients with Chronic Kidney Disease
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Abstract
Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
Journal
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- Acta Medica Okayama
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Acta Medica Okayama 68 (4), 219-233, 2014-08
Okayama University Medical School
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Details 詳細情報について
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- CRID
- 1390290699796075648
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- NII Article ID
- 120005465585
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- NII Book ID
- AA00508441
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- ISSN
- 0386300X
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- PubMed
- 25145408
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- PubMed
- CiNii Articles
- Crossref