Total synthesis of (+)-azimine via diastereoselective aminopalladation
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The aminopalladation of amino allylic alcohol using Cl2Pd(MeCN)(2) in CH2Cl2 gave the 2,6-disubstituted piperidine with excellent diastereoselectivity. This compound was successfully converted into (+)-azimine (1) using cross-metathesis and Shiina macrolactonization.
TETRAHEDRON 69(39), 8349-8352, 2013-09-30
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