Low-grade B-cell lymphoma presenting primarily in the bone marrow

• Iwatani, Kayoko

• Takata, Katsuyoshi

• Sato, Yasuharu

• Miyata-Takata, Tomoko

• Iwaki, Noriko

• Cui, Wei

• Sawada-Kitamura, Seiko

• Sonobe, Hiroshi

• Tamura, Maiko

• Saito, Katsuhiko

• Miyatani, Katsuya

• Yamasaki, Rie

• Yamadori, Ichiro

• Fujii, Nobuharu

• Terasaki, Yasushi

• Maeda, Yoshinobu

• Tanimoto, Mitsune

• Nakamura, Naoya

• Yoshino, Tadashi

抄録

Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.

収録刊行物

• Human Pathology

  Human Pathology 45 (7), 1379-1387, 2014-07

キーワード

• Low-grade B cell lymphoma
• Bone marrow
• LGBCL-NOS
• MYD88

詳細情報

• CRID: 1050846637416989312
• NII論文ID: 120005473076
• ISSN: 00468177
• Web Site: https://ousar.lib.okayama-u.ac.jp/52858
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles