Targeting TRPs in Neurodegenerative Disorders

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Abstract

Neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis present a significant medical challenge in the modern world. Recent evidence indicates that perturbation of neuronal Ca2+ homeostasis is involved in the pathogenesis of these neurodegenerative disorders. Transient receptor potential (TRP) channels are non-selective cation channels that are expressed in various cell types and tissues, and play an important role in regulating Ca2+ signaling in both non-neuronal and neuronal cells. TRP channels are related to the onset or progression of several diseases, and defects in the genes encoding TRP channels (so-called "TRP channelopathies") underlie certain neurodegenerative disorders due to their abnormal Ca2+ signaling properties. In this article, we review recent findings regarding the relationship between TRPs and neurodegenerative disorders, and discuss the therapeutic potential of targeting TRP channels pharmacologically.

Journal

  • Current Topics in Medicinal Chemistry

    Current Topics in Medicinal Chemistry 13(3), 322-334, 2013-03-01

    Bentham Science Publishers

Codes

  • NII Article ID (NAID)
    120005474465
  • NII NACSIS-CAT ID (NCID)
    AA11692499
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1568-0266
  • Data Source
    IR 
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