Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice
Abstract
The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis of body weight at 1, 3, 6, and 10 weeks after birth was performed on a population of 265 F2 intercross mice between the developed congenic strain and its background strain C57BL/6J. A significant QTL (named Pbwg1.10) affecting body weight at 6 and 10 weeks of age was identified within an approximately 21-Mb support interval. Surprisingly, Pbwg1.10 had an overdominance effect and caused heterosis for body weight. This result supported the overdominance hypothesis explaining heterosis.
Journal
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- Journal of Heredity
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Journal of Heredity 100 (4), 501-504, 2009-03
Oxford University Press
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Keywords
Details 詳細情報について
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- CRID
- 1050001338802603520
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- NII Article ID
- 120005475975
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- HANDLE
- 2237/20573
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- ISSN
- 00221503
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles