A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.

• 金井, 雅史

• Otsuka, Yoshihiko

• Otsuka, Kazunori

• Sato, Maremi

• Nishimura, Takafumi

• Mori, Yukiko

• Kawaguchi, Michiya

• Hatano, Etsuro

• Kodama, Yuzo

• Matsumoto, Shigemi

• Murakami, Yoshiki

• Imaizumi, Atsushi

• Chiba, Tsutomu

• Nishihira, Jun

• Shibata, Hiroyuki

抄録

A growing number of preclinical studies have demonstrated that curcumin could be a promising anticancer drug; however, poor bioavailability has been the major obstacle for its clinical application. To overcome this problem, we developed a new form of curcumin (Theracurmin) and reported high plasma curcumin levels could be safely achieved after a single administration of Theracurmin in healthy volunteers. In this study, we aimed to evaluate the safety of repetitive administration of Theracurmin in cancer patients.

収録刊行物

• Cancer chemotherapy and pharmacology

  Cancer chemotherapy and pharmacology 71 (6), 1521-1530, 2013-06

  Springer-Verlag

キーワード

• Curcumin
• Bioavailability
• Theracurmin®
• Gemcitabine
• Pancreatic cancer
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols/administration & dosage
• Antineoplastic Combined Chemotherapy Protocols/adverse effects
• Antineoplastic Combined Chemotherapy Protocols/chemistry
• Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics
• Biliary Tract Neoplasms/drug therapy
• Biliary Tract Neoplasms/metabolism
• Biliary Tract Neoplasms/mortality
• Biological Availability
• Curcumin/administration & dosage
• Curcumin/adverse effects
• Curcumin/chemistry
• Curcumin/pharmacokinetics
• Cytokines/antagonists & inhibitors
• Cytokines/immunology
• Disease-Free Survival
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Compounding
• Drug Stability
• Female
• Humans
• Male
• Maximum Tolerated Dose
• Middle Aged
• NF-kappa B/antagonists & inhibitors
• Pancreatic Neoplasms/drug therapy
• Pancreatic Neoplasms/metabolism
• Pancreatic Neoplasms/mortality
• Quality of Life
• Solubility

詳細情報

• CRID: 1050282810773585536
• NII論文ID: 120005477228
• NII書誌ID: AA00598397
• ISSN: 03445704
• HANDLE: 2433/189888
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles