Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy

• Oshima, Masamitsu

• Inoue, Kaoru

• Nakajima, Kei

• Tachikawa, Tetsuhiko

• Yamazaki, Hiromichi

• Isobe, Tomohide

• Sugawara, Ayaka

• Ogawa, Miho

• Tanaka, Chie

• Saito, Masahiro

• Kasugai, Shohei

• Takano-Yamamoto, Teruko

• Inoue, Takashi

• Tezuka, Katsunari

• Kuboki, Takuo

• Yamaguchi, Akira

• Tsuji, Takashi

抄録

Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.

収録刊行物

• Scientific Reports

  Scientific Reports 4 6044-, 2014-08-13

  Springer Science and Business Media LLC

キーワード

• Multidisciplinary

詳細情報

• CRID: 1050283687526112768
• NII論文ID: 120005511028
• ISSN: 20452322
• DOI: 10.1038/srep06044
• Web Site: https://ousar.lib.okayama-u.ac.jp/52907
• Web Site: https://www.nature.com/articles/srep06044
• Web Site: https://www.nature.com/articles/srep06044.pdf
• 本文言語コード: en
• 資料種別: journal article
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