Unsaturated Fatty Acids in Fish Oil Play a Role in Adequate Fat Distribution to Plasma, Liver and White Adipose Tissue

• Shiba Sachiko

  Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

• Tsunoda Nobuyo

  Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

• Ito Kanako

  Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

• Wakutsu Masaki

  Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

• Muraki Etsuko

  Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

• Sonoda Mariko

  Department of Nutrition and Food Science, Faculty of Human Life and Environmental Sciences, Ochanomizu University

• Tam Phyllis S. Y.

  Department of Nutrition and Food Science, Faculty of Human Life and Environmental Sciences, Ochanomizu University

• Fujiwara Yoko

  Department of Nutrition and Food Science, Faculty of Human Life and Environmental Sciences, Ochanomizu University

• Ikemoto Shinji

  Department of Nutrition and Food Science, Faculty of Human Life and Environmental Sciences, Ochanomizu University Present address: Department of Human Nutrition, Faculty of Human Nutrition, Seitoku University

• Kasono Keizo

  Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

Abstract

The components bringing the effects of fish oil on glucose and lipid metabolism are unclear. We used hydrogenated fish oil, which has saturated fatty acids with the same carbon chain lengths as the unsaturated fatty acids in fish oil, to clarify the functions of these unsaturated fatty acids on the improvements in lipid and glucose metabolism in mice. Mice divided into 3 groups were fed different diets: fish oil diet (FO), hydrogenated fish oil diet (HFO), and soybean oil diet (SBO) as a control. Body weight gain and white adipose tissue weight in the HFO and FO groups were significantly decreased compared with those in the SBO group. However, in the HFO group, the triglyceride (TG) levels in plasma were significantly decreased, while the lipids levels in the liver were remarkably increased compared with those in the FO group. Regarding the fatty acid composition in the liver and white adipose tissue in the HFO group, in parallel with the up-regulation of stearoyl-CoA desaturase 1 mRNA, relative amounts of C16:1 and C18:1 were significantly increased. By contrast, blood glucose levels in the oral glucose tolerance test had not deteriorated in the HFO group. Our results indicate that unsaturated fatty acids in the FO diet decrease lipid levels in the liver and maintain the balance of lipid levels in plasma, liver and white adipose tissue; in addition, in the HFO group, C16:1 and C18:1 synthesized in the liver and white adipose tissue may improve glucose tolerance and lipid metabolism.

Journal

• Journal of Health Science

  Journal of Health Science 57 (4), 341-349, 2011

  The Pharmaceutical Society of Japan

Keywords

• fish oil
• unsaturated fatty acid
• palmitoleic acid
• oleic acid

Details

• CRID: 1390001204498546944
• NII Article ID: 130001001078
• NII Article ID: 120005520790
• NII Book ID: AA11316464
• DOI: 10.1248/jhs.57.341
• ISSN: 13475207
• ISSN: 13449702
• NDL BIB ID: 11173808
• Web Site: http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-jhs.57.341
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11173808
• Web Site: https://www.jstage.jst.go.jp/article/jhs/57/4/57_4_341/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012103647
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed