Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation.

• 大守, 伊織

• Kawakami, Nozomi

• Liu, Sumei

• Wang, Haijiao

• Miyazaki, Ikuko

• Asanuma, Masato

• Michiue, Hiroyuki

• Matsui, Hideki

• Mashimo, Tomoji

• Ouchida, Mamoru

抄録

Developmental disorders including cognitive deficit, hyperkinetic disorder, and autistic behaviors are frequently comorbid in epileptic patients with SCN1A mutations. However, the mechanisms underlying these developmental disorders are poorly understood and treatments are currently unavailable. Using a rodent model with an Scn1a mutation, we aimed to elucidate the pathophysiologic basis and potential therapeutic treatments for developmental disorders stemming from Scn1a mutations.

収録刊行物

• Epilepsia

  Epilepsia 55 (10), 1558-1567, 2014-10

  Wiley Periodicals, Inc.

キーワード

• Methylphenidate
• Dopamine
• Mesolimbic reward pathway
• Scn1a
• Developmental disorders

詳細情報

• CRID: 1050845760729882240
• NII論文ID: 120005522498
• ISSN: 15281167
• HANDLE: 2433/192476
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles