Unusual clinical course of preeclampsia heralded by generalized edema

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Preeclampsia monitored by the amount of proteinuria usually does not show amelioration during pregnancy. A 37-year-old nulliparous woman was admitted to our hospital at gestational week (GW) 24-1/7 due to rapid weight gain (6.2 kg/4 weeks) and oligohydramnios. Hypertension (151/91 mmHg) appeared atGW25-0/7 and proteinuria not detected at GW 24-0/7 became significant (0.55 g/day) at GW 25-2/7. During the 2 successive weeks after administration of betamethasone at 12 mg twice and transabdominal amnioinfusion with 250 mL of Ringer’s acetate solution at GW 25-3/7, generalized edema, proteinuria and thrombocytopenia markedly improved: bodyweight, 78.0 to 69.0 kg; proteinuria, from 7.1 to 1.3 g/day; and platelet count, from 111 to 230 ¥ 109/L. However, intrauterine infection accompanied by non-reassuring fetal status necessitated emergency cesarean section at GW 28-3/7. Extraordinary bodyweight gain can herald the occurrence of preeclampsia and this weight gain together with signs of preeclampsia can ameliorate even during pregnancy, although its mechanism is unclear.

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