The Anti-Tumor Effect of Cyclic Polylactate

• NODAKE, Yuichi

• FUKASAWA, Masashi

• SAKAKIBARA, Ryuzo

• 野嶽, 勇一

• 深澤, 昌史

• 榊原, 隆三

Bibliographic Information

Other Title

• 環状重合乳酸のガン細胞増殖抑制効果
• カンジョウ ジュウゴウ ニュウサン ノ ガン サイボウ ゾウショク ヨクセイ コウカ

Abstract

A novel supramolecular oligomer, cyclic polylactate (CPL), was originally discovered in the culture medium of tumor cells. CPL suppresses the growth of tumor cells by inhibiting the activities of enzymes involved in the glycolytic pathway, pyruvate kinase and lactate dehydrogenase. Application of CPL was found to induce apoptosis in tumor cells through 7A6 antigen expression and DNA ladder formation. In addition, CPL is reported to prolong significantly the survival period of tumor bearing mice. These findings suggest that CPL might be a useful chemotherapeutic agent for cancers.

Journal

• Nagasaki International University Review

  Nagasaki International University Review 10 239-248, 2010-03

  長崎国際大学

Keywords

• 環状重合乳酸
• ガン細胞増殖抑制
• 解糖系
• ピルビン酸キナーゼ
• 乳酸脱水素酵素
• Cyclic polylactate
• anti-tumor effect
• glycolysis
• pyruvate kinase
• lactate dehydrogenase

Details

• CRID: 1050282813198268544
• NII Article ID: 120005578652
• NII Book ID: AA11766493
• ISSN: 13464094
• NDL BIB ID: 10718986
• Web Site: https://niu.repo.nii.ac.jp/records/805
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10718986
• Text Lang: ja
• Article Type: departmental bulletin paper
• Data Source:
  • IRDB
  • NDL
  • CiNii Articles
  • KAKEN