Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases.
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抄録
Although the association between CYP3A5 polymorphism and blood concentration of tacrolimus (TAC) in patients with solid organ transplantation was established, whether the association is also true in patients with connective tissue disease (CTD) who usually receive small amount of TAC is uncertain. Here, we performed a quantitative linear regression analysis to address the association between CYP3A5 and blood TAC concentration in patients with CTD. A total of 72 patients with CTD were recruited in the current study and genotyped for rs776746 in CYP3A5, which showed strong association with TAC concentration in patients with solid organ transplantation. The blood trough concentration of TAC after taking 3 mg per day was retrospectively obtained for each patient. As a result, allele A of rs776746 showed a significant association with a decreasing blood concentration of TAC (P=0.0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD.
収録刊行物
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- Journal of human genetics
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Journal of human genetics 59 (2), 107-109, 2014-02
Nature Publisheng Group
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キーワード
- KCNH2
- KCNQ1
- long QT syndrome
- psychotropic drugs
- sudden death
- Adult
- Aged
- Connective Tissue Diseases/drug therapy
- Connective Tissue Diseases/enzymology
- Connective Tissue Diseases/genetics
- Cytochrome P-450 CYP3A/genetics
- Cytochrome P-450 CYP3A/metabolism
- Female
- Humans
- Immunosuppressive Agents/administration & dosage
- Immunosuppressive Agents/pharmacokinetics
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Tacrolimus/administration & dosage
- Tacrolimus/pharmacokinetics
詳細情報 詳細情報について
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- CRID
- 1050845760740821120
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- NII論文ID
- 120005587802
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- NII書誌ID
- AA11206160
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- ISSN
- 14345161
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- HANDLE
- 2433/196846
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- NDL書誌ID
- 025287074
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- NDL
- CiNii Articles