Prefrontal abnormality in children with adhd during cognitive interference control : a functional nirs study
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Aim: Children with attention-deficit/hyperactivity disorder (ADHD) show cognitive impairments such as disrupted attention and impaired learning and memory. The multi-source interference task (MSIT) combines multiple dimensions of cognitive interference and recruits the cingulo-frontal-parietal cognitive/attention network. The aim of this study was to determine whether children with ADHD show fronto-parietal dysfunction during the MSIT by using functional near-infrared spectroscopy (NIRS). Methods: Nineteen boys with ADHD and 14 age- and IQ-matched controls were studied. We measured oxygenated hemoglobin concentration ([oxy-Hb]) changes in the fronto-parietal region by using a 46-channel functional NIRS imaging system. The behavioral performance and mean [oxy-Hb] of the two groups during the MSIT were compared.Results: The behavioral data of the MSIT were not significantly different between the two groups. Compared to the control group, the ADHD group showed higher [oxy-Hb] changes in the left dorsolateral prefrontal region (ADHD, 0.17 × 10^-1 ±0.11; control, -0.65 × 10^-1 ± 0.62 ×10^-1; P = 0.02). Conclusion: Our results suggest that compared to controls, children with ADHD have abnormal prefrontal activation in response to multiple interference control, in order to achieve favorable outcomes of cognitive demand. These findings may provide insights into the pathophysiology of ADHD.
- The bulletin of the Yamaguchi Medical School
The bulletin of the Yamaguchi Medical School 61(3-4), 37-47, 2014
Yamaguchi University School of Medicine