Sugar-responsive pseudopolyrotaxanes and their application in sugar-induced release of PEGylated insulin

Access this Article

Search this Article

Abstract

We have designed a pseudopolyrotaxane (PPRX), known as a molecular necklace, consisting of phenylboronic acid-modified γ-cyclodextrin (PBA-γ-CyD) and naphthalene-modified polyethylene glycol (Naph-PEG) for developing sugar-responsive insulin delivery systems. Interestingly, structural analyses show that the Naph-PEG/PBA-γ-CyD PPRX obtained by our method was single stranded, whereas ordinary PPRXs using parent γ-CyD were double stranded. The Naph-PEG/PBA-γ-CyD PPRX was poorly water soluble at pH 7.4; however, sugar addition induced disintegration of the PPRX, and the components were dissolved, suggesting that the PBA moiety acts as a sugar sensor. We also have developed a PPRX consisting of Naph-PEG-appended insulin (Naph-PEG-Ins) and PBA-γ-CyD and have confirmed that the release rate of Naph-PEG-Ins was accelerated following sugar addition.This is a post-peer-review, pre-copyedit version of an article published in Journal of Inclusion Phenomena and Macrocyclic Chemistry. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10847-015-0504-0

Journal

  • Journal of inclusion phenomena and macrocyclic chemistry

    Journal of inclusion phenomena and macrocyclic chemistry 82(3-4), 417-424, 2015-03-26

    Springer

Codes

  • NII Article ID (NAID)
    120005624873
  • NII NACSIS-CAT ID (NCID)
    AA12422343
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1388-3127
  • Data Source
    IR 
Page Top