Regulation of the Human Platelet-derived Growth Factor B-chain Gene

• Takimoto, Yasuo

• Kuramoto, Atsushi

抄録

Human platelet-derived growth factor (PDGF) B chain is a cellular homologue of v-sis, closely involved in cell growth and oncogenicity. Analysis in this study showed the importance of not only the region near the TATAA box but also the fragment －355 bases or more upstream in the expression of the PDGF-B chain gene. However, tissue specificity was not clear in the 5' upstream region alone, and regulation by gene methylation or by elements other than in the 5' region seemed to be necessary. In A172 cells, the half-life of mRNA was much shorter in the PDGF-B chain (<2 hours) than in the PDGF-A chain (7 hours). Regulation of the PDGF-B chain gene may markedly differ from that of the PDGF-A chain gene not only at the transcriptional level but also at the post-transcriptional level.

収録刊行物

• Hiroshima Journal of Medical Sciences

  Hiroshima Journal of Medical Sciences 42 (4), 137-142, 1993-12

  Hiroshima University Medical Press

キーワード

• PDGF-B chain gene
• Transcription
• Half life

詳細情報

• CRID: 1050014791008546048
• NII論文ID: 120005625705
• NII書誌ID: AA00664312
• Web Site: http://ir.lib.hiroshima-u.ac.jp/00037928
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles