A single-center analysis of the survival benefits of adjuvant gemcitabine chemotherapy for biliary tract cancer.
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[Background]Surgical resection is the only curative treatment of biliary tract cancer (BTC). However, the prognosis of BTC remains unsatisfactory. The aim of this study is to evaluate the benefits of adjuvant gemcitabine chemotherapy for BTC. [Methods]We performed a historical cohort study that involved 198 patients who underwent R0 surgical resection. Patients who underwent major hepatectomy were administered biweekly intravenous gemcitabine at a dose of 800 mg/m2. Otherwise, patients were administered intravenous gemcitabine at a dose of 1, 000 mg/m2 in 3 weekly infusions, which were followed by a 1-week pause. The primary outcome was overall survival. The hazard ratio (HR) of adjuvant chemotherapy was estimated by propensity score-stratified Cox regression that was adjusted for confounders. [Results]Forty patients received adjuvant chemotherapy. The HR of adjuvant chemotherapy was 0.47 [95 % confidence interval (CI) 0.28–0.95; P = 0.03]. Subgroup analysis showed that the survival benefits were possibly modified by lymph node positivity (HR 0.19; 95 % CI 0.07–0.58; interaction, P = 0.22), stage III (HR 0.11; 95 % CI 0.02–0.50; interaction, P < 0.01), intrahepatic cholangiocarcinoma (ICC) (HR 0.09; 95 % CI 0.01–0.67; interaction, P = 0.05), and poorly differentiated tumor (HR 0.16; 95 % CI 0.03–0.85; interaction, P = 0.13). [Conclusions]Adjuvant gemcitabine chemotherapy for BTC may be effective, particularly for patients with stage III and ICC.
収録刊行物
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- International journal of clinical oncology
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International journal of clinical oncology 19 (3), 485-489, 2014-06
Springer Japan
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キーワード
- Gemcitabine
- Adjuvant chemotherapy
- Biliary tract cancer
- Aged
- Antimetabolites, Antineoplastic/adverse effects
- Antimetabolites, Antineoplastic/therapeutic use
- Biliary Tract Neoplasms/drug therapy
- Biliary Tract Neoplasms/mortality
- Biliary Tract Neoplasms/surgery
- Chemotherapy, Adjuvant
- Deoxycytidine/adverse effects
- Deoxycytidine/analogs & derivatives
- Deoxycytidine/therapeutic use
- Female
- Hepatectomy
- Humans
- Male
- Neoplasm Recurrence, Local
- Treatment Outcome
詳細情報 詳細情報について
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- CRID
- 1050282810790349568
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- NII論文ID
- 120005652822
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- NII書誌ID
- AA11086579
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- ISSN
- 13419625
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- HANDLE
- 2433/199895
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles