Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma : comprehensive immunohistochemical study using a tissue microarray

• Nitta, T.

• Mitsuhashi, Tomoko

• Hatanaka, Y.

• Miyamoto, M.

• Oba, K.

• Tsuchikawa, T.

• Suzuki, Y.

• Hatanaka, K. C.

• Hirano, S.

• Matsuno, Y.

抄録

Supplementary Information accompanies this paper on British Journal of Cancer website.

Background: Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express different isoforms of the cadherin transmembrane protein and usually refers to a switch from the expression of E-cadherin to N-cadherin, is one aspect of EMT and can have a profound effect on tumour invasion/metastasis. The aim of this study was to investigate the clinicopathological significance of EMT-related proteins and cadherin switch in extrahepatic cholangiocarcinoma (EHCC). Methods: We investigated the association between altered expression of 12 EMT-related proteins and clinical outcomes in patients with EHCC (n = 117) using immunohistochemistry on tissue microarrays. Results: Univariate and multivariate analyses revealed that, in addition to N classification (P = 0.0420), the expression of E-cadherin (P = 0.0208), N-cadherin (P = 0.0038) and S100A4 (P = 0.0157) was each an independent and a significant prognostic factor. We also demonstrated that cadherin switch was independently associated with poor prognosis (P = 0.0143) in patients with EHCC. Conclusions: These results may provide novel information for selection of patients with EHCC who require adjuvant therapy and strict surveillance.

収録刊行物

• British Journal of Cancer

  British Journal of Cancer 111 (7), 1363-1372, 2014-09-23

  Nature Publishing Group

キーワード

• EMT
• extrahepatic cholangiocarcinoma
• immunohistochemistry
• tissue microarray
• prognosis
• survival
• cadherin switch

詳細情報

• CRID: 1050282813993715840
• NII論文ID: 120005656331
• DOI: 10.1038/bjc.2014.415
• ISSN: 15321827
• ISSN: 00070920
• HANDLE: 2115/59851
• Web Site: http://www.nature.com/articles/bjc2014415.pdf
• Web Site: http://www.nature.com/articles/bjc2014415
• 本文言語コード: en
• 資料種別: journal article
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