Boosting of activity enhancement of K(+)-responsive quadruplex hammerhead ribozyme.

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Abstract

Accepted 13 Feb 2015.Two second-generation quadruplex hammerhead ribozymes, whose activity enhances in response to K(+)via quadruplex formation of embedded r(GGA)3GG, were developed. Different strategies were applied to suppress basal activity when K(+) is absent. As a result, the activity enhancement upon the addition of K(+) has reached as high as 21-fold.

Journal

  • Chemical communications

    Chemical communications 51(27), 5898-5901, 2015-03-02

    Royal Society of Chemistry

Codes

  • NII Article ID (NAID)
    120005657931
  • NII NACSIS-CAT ID (NCID)
    AA11071130
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1359-7345
  • Data Source
    IR 
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