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Abstract

Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound-termed "SAHA-PIP X"-from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs).

Journal

  • Chembiochem

    Chembiochem 16(10), 1497-1501, 2015-05-28

    wiley

Codes

  • NII Article ID (NAID)
    120005670900
  • NII NACSIS-CAT ID (NCID)
    AA11497584
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1439-7633
  • Data Source
    IR 
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