A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts.
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Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound-termed "SAHA-PIP X"-from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs).
Chembiochem 16(10), 1497-1501, 2015-05-28