A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts.

• Syed, Junetha

• Chandran, Anandhakumar

• Pandian, Ganesh N

• Taniguchi, Junichi

• Sato, Shinsuke

• Hashiya, Kaori

• Kashiwazaki, Gengo

• Bando, Toshikazu

• 杉山, 弘

抄録

Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound-termed "SAHA-PIP X"-from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs).

収録刊行物

• Chembiochem

  Chembiochem 16 (10), 1497-1501, 2015-05-28

  wiley

キーワード

• artificial transcription activators
• DNA recognition
• gene expression
• histone acetylation
• transcription profiling

詳細情報

• CRID: 1050001335816346880
• NII論文ID: 120005670900
• NII書誌ID: AA11497584
• ISSN: 14397633
• HANDLE: 2433/201619
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles