Simultaneous determination of coinage metals, copper, silver and gold in tissues using electrospray ionization tandem mass spectrometry

• Minakata, Kayoko

• Yamagishi, Itaru

• Nozawa, Hideki

• Gonmori, Kunio

• Hasegawa, Koutaro

• Suzuki, Masako

• Horio, Fumihiko

• Watanabe, Kanako

• Suzuki, Osamu

Abstract

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A rapid and sensitive mass spectrometric method was developed for the simultaneous determination of coinage metals such as copper (Cu), silver (Ag) and gold (Au). The metals in a wet ashed tissue solution were complexed with diethyldithiocarbamate (DDC; C4H10NCS2) and were extracted together with isoamyl alcohol. After the acidification of the extract with oxalic acid, metals were quantified using their product ions, Cu(DDCH)+, Ag(DDCH) + and Au(DDCH)+ that derived from the precursor ions Cu(DDC)2+, Ag(DDC)2 + and Au(DDC)2+, respectively, by electrospray ionization tandem mass spectrometry. The limits of detection were 0.6, 0.3 and 1 μgl?1 for Cu, Ag and Au and the quantification ranges were 2 ? 100, 1 ? 100 and 3 ? 100 μgl?1 for Cu, Ag and Au, respectively. Cu levels in spontaneously hypertensive osteogenic disorder rats at 6 weeks old and at 30 weeks old were found to be 1.8 times and 5.1 times those of the normotensive osteogenic disorder rats, respectively, when using wet-ashed kidney solutions diluted to 1,000 fold.

Journal

• Forensic Toxicology

  Forensic Toxicology 30 (2), 149-155, 2012-07

  Springer Japan

Keywords

• Copper
• Silver
• Gold
• Electrospray ionization
• Tandem mass spectrometry
• Diethyldithiocarbamate

Details

• CRID: 1050001201673910144
• NII Article ID: 120005671501
• DOI: 10.1007/s11419-012-0134-9
• ISSN: 18608973
• ISSN: 18608965
• HANDLE: 10271/2909
• Web Site: https://hama-med.repo.nii.ac.jp/records/2771
• Web Site: http://link.springer.com/content/pdf/10.1007/s11419-012-0134-9.pdf
• Web Site: http://link.springer.com/article/10.1007/s11419-012-0134-9/fulltext.html
• Web Site: http://link.springer.com/content/pdf/10.1007/s11419-012-0134-9
• Web Site: https://search.jamas.or.jp/link/ui/2013185519
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN