Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment.

• Yamada, Hisatsugu

• Hasegawa, Yoshinori

• Suzuki, Yuki

• Imai, Hirohiko

• Matsuda, Tetsuya

• Kimura, Yu

• Toshimitsu, Akio

• Aoyama, Yasuhiro

• 近藤, 輝幸

抄録

A (13)C-enriched phosphorylcholine polymer ((13)C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(-) (pancreatic) tumors, the antibody-tag conjugate (13)C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the (1)H-(13)C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged.

収録刊行物

• Bioorganic & medicinal chemistry letters

  Bioorganic & medicinal chemistry letters 25 (13), 2675-2678, 2015-07-01

  Elsevier Ltd.

キーワード

• Tumor imaging
• MRI
• Self-traceable polymer
• Anti-Her2 antibody
• Active targeting

詳細情報

• CRID: 1050564285769833216
• NII論文ID: 120005672621
• NII書誌ID: AA1079577X
• ISSN: 0960894X
• DOI: 10.1016/j.bmcl.2015.04.072
• HANDLE: 2433/201953
• Web Site: https://api.elsevier.com/content/article/PII:S0960894X15004047?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0960894X15004047?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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