An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions
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- Hideharu Abe
- editor
書誌事項
- タイトル別名
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- Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.
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抄録
[Background]Neutrophil gelatinase-associated lipocalin (NGAL or LCN2) is an iron-transporting factor which possesses various activities such as amelioration of kidney injury and host defense against pathogens. Its circulating concentrations are elevated in acute and chronic kidney diseases and show a positive correlation with poor renal outcome and mortality, but its clinical significance in maintenance hemodialysis (HD) patients remains elusive. [Methods]Serum NGAL levels were determined by enzyme-linked immunosorbent assay in out-patient, Japanese HD subjects. Their correlation to laboratory findings and morbidity (as development of severe infection or serum albumin reduction) was investigated using linear regression analysis and χ2 test.[Results]Pre-dialysis serum NGAL levels in HD patients were elevated by 13-fold compared to healthy subjects (n=8, P<0.001). In a cross-sectional study of 139 cases, serum NGAL concentrations were determined independently by % creatinine generation rate (an indicator of muscle mass, standardized coefficient β=0.40, P<0.001), peripheral blood neutrophil count (β=0.38, P<0.001) and anion gap (which likely reflects dietary protein intake, β=0.16, P<0.05). Iron administration to anemic HD patients caused marked elevation of peripheral blood hemoglobin, serum ferritin and iron-regulatory hormone hepcidin-25 levels, but NGAL levels were not affected. In a prospective study of 87 cases, increase in serum albumin levels a year later was positively associated to baseline NGAL levels by univariate analysis (r=0.36, P<0.01). Furthermore, within a year, patients with the lowest NGAL tertile showed significantly increased risk for marked decline in serum albumin levels (≥0.4 g/dl; odds ratio 5.5, 95% confidence interval 1.5–20.3, P<0.05) and tendency of increased occurrence of severe infection requiring admission (odds ratio 3.1, not significant) compared to the middle and highest tertiles. [Conclusion]Low serum NGAL levels appear to be associated with current malnutrition and also its progressive worsening in maintenance HD patients.
収録刊行物
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- PloS one
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PloS one 10 (7), 99-106, 2015-07-10
Public Library of Science
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キーワード
- Acute kidney injury
- Neutrophil
- Sepsis, bone marrow transplantation
- Biomarker
- Acute Kidney Injury/blood
- Acute-Phase Proteins/urine
- Animals
- Bacterial Infections/blood
- Bacterial Infections/urine
- Biological Markers/blood
- Biological Markers/urine
- CCAAT-Enhancer-Binding Proteins/genetics
- CCAAT-Enhancer-Binding Proteins/physiology
- Hematologic Neoplasms/complications
- Hematologic Neoplasms/therapy
- Hematopoietic Stem Cell Transplantation
- Humans
- Kidney/metabolism
- Lipocalins/blood
- Lipocalins/urine
- Mice
- Mice, Knockout
- Molecular Weight
- Neutrophils/metabolism
- Oncogene Proteins/blood
- Oncogene Proteins/urine
詳細情報 詳細情報について
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- CRID
- 1050001335818815104
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- NII論文ID
- 120005678176
- 120005678175
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- NII書誌ID
- AA11126935
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- ISSN
- 19326203
- 13421751
- 14377799
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- HANDLE
- 2433/202581
- 2433/202580
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- Web Site
- http://link.springer.com/content/pdf/10.1007/s10157-014-0952-7.pdf
- http://link.springer.com/article/10.1007/s10157-014-0952-7/fulltext.html
- http://link.springer.com/content/pdf/10.1007/s10157-014-0952-7
- http://dx.plos.org/10.1371/journal.pone.0132539
- https://search.jamas.or.jp/link/ui/2016000142
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- CiNii Articles
- KAKEN