Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish
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Zebrafish can regenerate several organs such as the tail fin, heart, central nervous system, and photoreceptors. Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)- induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. The research has also shown massive proliferation of Müller cells within a week. To address the question of whether proliferating Müller cells are the source of regenerating photoreceptors, which remains unknown in the MNU-induced zebrafish RD model, we employed a BrdU pulse-chase technique to label the proliferating cells within a week after MNU treatment. As a result of the BrdU pulse-chase technique, a number of BrdU+ cells were observed in the outer nuclear layer as well as the inner nuclear layer. This implies that regenerating photoreceptors are derived from proliferating Müller cells in the zebrafish MNU-induced RD model. © Springer International Publishing Switzerland 2016.
[Book Chapter]
収録刊行物
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- Advances in Experimental Medicine and Biology
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Advances in Experimental Medicine and Biology 854 685-692, 2016-10-01
Springer
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詳細情報 詳細情報について
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- CRID
- 1390859758186645120
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- NII論文ID
- 120005682636
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- NII書誌ID
- AA00512642
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- ISSN
- 00652598
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- Web Site
- http://hdl.handle.net/2297/43910
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles