Copper-catalyzed stereoselective conjugate addition of alkylboranes to alkynoates

• Wakamatsu, Takamichi

• Nagao, Kazunori

• Ohmiya, Hirohisa

• Sawamura, Masaya

抄録

A copper-catalyzed conjugate addition of alkylboron compounds (alkyl-9-BBN, prepared by hydroboration of alkenes with 9-BBN-H) to alkynoates to form beta-disubstituted acrylates is reported. The addition occurred in a formal syn-hydroalkylation mode. The syn stereoselectivity was excellent regardless of the substrate structure. A variety of functional groups were compatible with the conjugate addition.

収録刊行物

• Beilstein journal of organic chemistry

  Beilstein journal of organic chemistry 11 2444-2450, 2015-12-04

  Beilstein-Institut

キーワード

• alkylborane
• alkynoate
• conjugate addition
• copper
• multisubstituted alkene

詳細情報

• CRID: 1050001339019362560
• NII論文ID: 120005690892
• DOI: 10.3762/bjoc.11.265
• HANDLE: 2115/60521
• ISSN: 18605397
• Web Site: https://www.beilstein-journals.org/bjoc/articles/11/265
• Web Site: https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-11-265.pdf
• Web Site: http://www.beilstein-journals.org/bjoc/content/11/1/265
• 本文言語コード: en
• 資料種別: journal article
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