Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

• Takano, Hironobu

• Nakamura, Toru

• Tsuchikawa, Takahiro

• Kushibiki, Toshihiro

• Hontani, Kouji

• Inoko, Kazuho

• Takahashi, Mizuna

• Sato, Shoki

• Abe, Hirotake

• Takeuchi, Shintaro

• Sato, Nagato

• Hiraoka, Kei

• Nishihara, Hiroshi

• Shichinohe, Toshiaki

• Hirano, Satoshi

抄録

Ephrin receptor A4 (EphA4) is overexpressed in human pancreatic adenocarcinoma (PDAC) and activate cell growth. Recent studies have identified small molecules that block EphA4. In this study, we investigated the correlation between EphA4 expression and the prognosis of patients with PDAC. We also examined the cytostatic efficacy of 2,5-dimethylpyrrolyl benzoic acid (compound 1), a small molecule that blocks EphA4, in PDAC cells. Overall survival of patients with EphA4 positivity was significantly shorter than that of patients with EphA4 negativity (P = 0.029). In addition, multivariate analysis revealed that EphA4 expression was an independent prognostic factor in PDAC patients (P = 0.039). Compound 1 showed a cytostatic efficacy in PDAC cells expressing EphA4 in vitro and in vivo. Our study indicated that compound 1 suppressed both EphA4 and Akt phosphorylations, and induced apoptosis in PDAC cells expressing EphA4. In conclusion, compound 1 has a high potential as a therapeutic agent for patients with PDAC.

収録刊行物

• Oncotarget

  Oncotarget 6 (38), 41063-41076, 2015-10-19

  Impact Journals

キーワード

• EphA4
• prognostic factor
• 2,5-dimethylpyrrolyl benzoic acid
• human pancreatic cancer
• orthotopic models

詳細情報

• CRID: 1050282813996098816
• NII論文ID: 120005697203
• HANDLE: 2115/60647
• ISSN: 19492553
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles