Total Synthesis of Mycalolides A and B through Olefin Metathesis
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An asymmetric total synthesis of the trisoxazole marine macrolides mycalolides A and B is described. This synthesis involves the convergent assembly of highly functionalized C1–C19 trisoxazole and C20–C35 side-chain segments through the use of olefin metathesis and esterification as well as Julia–Kocienski olefination and enamide formation as key steps.
- Angewandte Chemie International Edition
Angewandte Chemie International Edition 54(47), 14174-14178, 2015-11