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Abstract

An asymmetric total synthesis of the trisoxazole marine macrolides mycalolides A and B is described. This synthesis involves the convergent assembly of highly functionalized C1–C19 trisoxazole and C20–C35 side-chain segments through the use of olefin metathesis and esterification as well as Julia–Kocienski olefination and enamide formation as key steps.

Journal

  • Angewandte Chemie International Edition

    Angewandte Chemie International Edition 54(47), 14174-14178, 2015-11

    Wiley-VCH

Keywords

Codes

  • NII Article ID (NAID)
    120005708108
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1433-7851
  • Data Source
    IR 
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