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Abstract

Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue (AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a major protein secreted from SVF cells in human visceral AT. YKL-40 expression levels in SVF cells from visceral AT were higher than in those from subcutaneous AT. Immunofluorescence staining revealed that YKL-40 was exclusively expressed in macrophages among SVF cells. YKL-40 purified from SVF cells inhibited the degradation of type I collagen, a major extracellular matrix of AT, by matrix metalloproteinase (MMP)-1 and increased rate of fibril formation of type I collagen. The expression of MMP-1 in preadipocytes and macrophages was enhanced by interaction between these cells. These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation.

Journal

  • Biochemical and Biophysical Research Communications

    Biochemical and Biophysical Research Communications 388(3), 511-516, 2009-10-23

Codes

  • NII Article ID (NAID)
    120005708871
  • NII NACSIS-CAT ID (NCID)
    AA00564395
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0006-291X
  • Data Source
    IR 
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