Access this Article

Search this Article

Abstract

DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood. In this study, we investigated expression of DNAM-1 on monocyte subsets in mouse peripheral blood and found that only inflammatory monocytes (iMos), but not patrolling monocytes (pMos), expressed high levels of DNAM-1. In addition, we found that DNAM-1 was highly expressed on iMos, rather than pMos, also in human. Furthermore, we found that DNAM-1 on inflammatory monocytes was involved in cell adhesion to CD155-expressing cells. Therefore, we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes.

Journal

  • Molecular immunology

    Molecular immunology (69), 70-76, 2016-01

    Elsevier

Keywords

Codes

  • NII Article ID (NAID)
    120005723634
  • NII NACSIS-CAT ID (NCID)
    AA00307483
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0161-5890
  • Data Source
    IR 
Page Top